She started her theatre career at the Sheffield's Crucible Theatre in the play The Birthday Party by Harold Pinter.[2]

In 1993 she had her first film role, alongside Samantha Morton, in the musical comedy drama called The Token King, set in a high school in Nottingham. Lowe recently guest starred in two episodes of the second season of the Showtime hit show The Tudors in which she played Lady Eleanor Luke, a fictional noblewoman who is briefly the mistress of Henry VIII, and she played the role of Annie Cabbot in the British television network ITV two-part TV-Series DCI Banks: Aftermath, an adaptation of the 2002 Peter Robinson novel Aftermath