Nichol began his career in the entertainment industry as a commercial model. His acting debut started with a supporting role in the mini-series Kami Rindu Ayah in 2013. However, he rose to fame after starring in the film Dear Nathan in 2017, where he played Nathan, a teenager with a complex character.

Since then, Jefri has starred in various films and television series, showcasing his versatile acting abilities.

In addition to his acting career, Jefri is also known for being active on social media and has a large fan base. However, he has also faced controversies, including public attention on his personal life.