She made her television debut with the series Şen Yuva, in which played the role of Şehrazat. In 2011, she was cast in BKM programs by Meltem Bozoflu, titled "5'er Beşer" and "İnsanlar Alemi", in which she had the role of Sinem.

She played the cast of Kanal D's hit sitcom series Yalan Dünya, written by Gülse Birsel. Between 2015 and 2018, she starred in BKM sketch show Güldür Güldür. In 2017, she received the Best Supporting Actress award at the 28th Ankara International Film Festival for her role in Martı. She continued her cinematic career with roles in Dönerse Senindir, Ölümlü Dünya and Düğüm Salonu, and in 2019 she appeared in the drama series Bir Aile Hikayesi as Müjde Güneş. İrem Sak was joined The Pit Turkish TV series between 2020 and 2021 as Seren Erdenet. In 2022 she appeared in As The Crow Flies Netflix series as Müge, one of the four main characters of the story, with a remarkable performance.