Darshana hails from a non-filmy background. She made her film debut in the 2014 Malayalam film "John Paul Vaathil Thurakkunnu."

Darshana has established herself as a versatile actress by collaborating with renowned directors in diverse projects. She re-teamed with Aashiq Abu for the medical thriller "Virus" (2019), delivered poignant performances in Jis Joy's "Vijay Superum Pournamiyum" (2019) and Anjali Menon's "Koode" (2018), and showcased her acting skills in Vineeth Sreenivasan's "Hridayam" (2022). Her recent portrayal in Rajeev Ravi's historical drama "Thuramukham" further solidified her position as a serious actress capable of tackling challenging roles.

Darshana has also made her mark in Tamil cinema, starting with character roles in films like "Kavan" (2017) and "Irumbu Thirai" (2018). These roles allowed her to experiment with different languages and characters.

In 2022, Darshana took on the lead role in the Malayalam film "Jaya Jaya Jaya Jaya Hey," showcasing her range and ambition. This film further established her presence in the film industry.