Muldaur gained prominence through her work on television, appearing in notable series such as "The Twilight Zone," "The Streets of San Francisco," and "L.A. Law," where she portrayed the character of Rosalind Shays. Her film credits include roles in "The Last of the Mobile Hot Shots" and "The Taking of Pelham One Two Three."

She is also well-known for her role as Dr. Kate Pulaski in the iconic series "Star Trek: The Next Generation."

In addition to her screen work, Muldaur has an extensive background in theater, performing in productions both on and off Broadway. Her performances have earned her critical acclaim and a dedicated fan base.

Beyond her acting career, Muldaur has also made significant contributions as a director and producer.