Jackson began acting at the age of five, making her debut in the film Liberty Kid (2007). She has provided the voice of Glory Grant across the Marvel Rising series (2018–2019) and voiced Summer in the animated series DreamWorks Dragons: Rescue Riders (2019–2022). In 2019, Jackson released her debut book, Reach for the Skai: How to Inspire, Empower, and Clapback. The following year, she was a semi-finalist on the 29th season of Dancing with the Stars.