Agdal, who grew up in Hillerød, Denmark, has modeled for Billabong, Leonisa, Banana Moon Swimwear, Macy's, Frederick's of Hollywood, and Victoria's Secret. In 2012, she made her first appearance in the Sports Illustrated Swimsuit Issue and was subsequently named the issue's "Rookie of the Year" In 2014, she appeared on the 50th anniversary cover of the Sports Illustrated Swimsuit Issue with Chrissy Tiegen and Lily Aldridge.

Agdal appeared in a 2013 Super Bowl television commercial for Carl's Jr./Hardee's, following in the footsteps of Kim Kardashian, Padma Lakshmi, Paris Hilton and fellow Sports Illustrated Swimsuit Issue model Kate Upton.

Agdal was in a relationship with Max George of The Wanted from October 2013 to February 2014.