She rose to fame in the late 1970s as member of the hip hop trio The Sequence. In the early 1990s, she became a member of the R&B trio Vertical Hold. Stone would later release her solo debut Black Diamond (1999) on Arista Records, which was certified gold by the Recording Industry Association of America and spawned the single "No More Rain (In This Cloud)".

After transitioning to J Records, she released her second album, Mahogany Soul (2001), which included the hit single "Wish I Didn't Miss You"; followed by the albums Stone Love (2004) and The Art of Love & War (2007), her first number-one album on the US Billboard Top R&B/Hip-Hop Albums chart.

She ventured into acting in the 2000s, making her film debut in the 2002 comedy film The Hot Chick, and her stage debut in 2003, in the role of Big Mama Morton in the Broadway musical Chicago. She has since appeared in supporting roles in films and television series as well as several musical productions, including VH1’s Celebrity Fit Club and TV One's R&B Divas, and movies such as The Fighting Temptations (2003), Pastor Brown (2009) and School Gyrls (2010).