Previously he has presented The Chris Moyles Show on BBC Radio 1 from 2004 to 2012 and Chris Moyles' Quiz Night from 2009 to 2012 on Channel 4. Moyles has worked at various radio stations, including Radio Luxembourg (under the pseudonym Chris Holmes) and Capital FM. Moyles moved to BBC Radio 1 in July 1997 and left the station in September 2012. He has presented the early breakfast show, a Saturday morning show, and the drive time show (from September 1998 to December 2003), before presenting the breakfast show from 5 January 2004 to 14 September 2012. In September 2009, he became BBC Radio 1's longest serving breakfast presenter. Moyles has become famous for his maverick bad-boy broadcasting style on BBC Radio 1 and has been embroiled in numerous controversies, including accusations of sexism and homophobia, due to statements he has made on the air and in the press.

He frequently made appearances on several television shows including Hotel Babylon, a celebrity version of Dale's Supermarket Sweep, Top Gear, The Charlotte Church Show, The F-Word, The Friday Night Project, The One Show, Friday Night with Jonathan Ross, Richard & Judy and The Paul O'Grady Show.