In 1954, Mariani made starred role in the first Indonesian superhero film, Sri Asih, which nicknamed her as the first Sri Asih. She later married her co-star, Turino Djunaedy, in 1955. She was most productive in that year, when she appeared in four more films: Rahasia Sukudomas (1954), Putri Gunung (1954), Djubah Hitam (1954), and Debu Revolusi (1954). She also starred in Oh, Ibuku (1955) and Ibu dan Putri (1955), a movie from Gadis Tiga Djaman series directed by Ali Yugo.
After Indonesian film industry crisis and her divorce from Djunaedy, Mariani left the industry and went to theatre. She returned to film in two years later, where she starred in Nina (1960) and Limapuluh Megaton (1961). Her two last film, a minor role in Cheque AA (1966) and B-29 (1968).
After her last marriage to Semiarto Suharto, founder of Titi Murni Pharmacy, she converted to Islam and changed her name to Sumiarto Suharto. In 1969, she was diagnosed with lymphoma which required her to underwent surgery twice. But due to the cancer already spreading to her spleen, the doctor forbid her from going through with the third operation, and she later went into bed rest for five months. She later slipped into coma and died at her house in Kebon Kelapa, Gambir, on May 1, 1971, at the age of 42. Her funeral was held at Karet Bivak Cemetery on the next day, and was attended by several film figures such as Fifi Young, Sofia W.D., W.D. Mochtar, S. Poniman, Aminah Banowati, and Wolly Sutinah.
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